Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC035
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-06 07:40
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 4x1/2 caps MadoparHBS a 125mg 2 uvece tbl Mirapexin a 0,52mg jerdna ujutru tbl Sermion a 30mg jedna ujutru Older patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 30 individuals with a value less than 0.63 were subsequently diagnosed with PD. That is, 71.43% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.63 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 33, 'TN': 25, 'TP': 9, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 40, 'TN': 29, 'TP': 2, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 14, 'TP': 22, 'FP': 16}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 17.952
timePerCircleCoV 0.209223
timePerCircleSlope -0.0551774
meanError 1.36549
tremorFreq 6.15234
tremorRelPower 32.571
tremorGyroAmpMean 0.0111084
tremorGyroAmpSlope -0.000870118
tremorGyroAmpCoV 0.408622
tremorCoordAmpMean 0.03316
tremorCoordAmpSlope 0.00120084
tremorCoordAmpCoV 1.34653
tremorAccAmpMean 0.0693771
tremorAccAmpSlope -0.000349451
tremorAccAmpCoV 0.101785
tremorPcRelVar 0.797133
tremorPcX -0.648793
tremorPcY -0.760965

Circle Segment 1

Duration 27.4 s, Accuracy Estimate 2.547 (lower is better)

Circle Segment 2

Duration 20.36 s, Accuracy Estimate 0.913 (lower is better)

Circle Segment 3

Duration 17.12 s, Accuracy Estimate 1.029 (lower is better)

Circle Segment 4

Duration 18.12 s, Accuracy Estimate 0.886 (lower is better)

Circle Segment 5

Duration 17.84 s, Accuracy Estimate 1.175 (lower is better)

Circle Segment 6

Duration 15.68 s, Accuracy Estimate 1.156 (lower is better)

Circle Segment 7

Duration 16.72 s, Accuracy Estimate 1.424 (lower is better)

Circle Segment 8

Duration 16.76 s, Accuracy Estimate 1.408 (lower is better)

Circle Segment 9

Duration 15.92 s, Accuracy Estimate 1.089 (lower is better)

Circle Segment 10

Duration 13.6 s, Accuracy Estimate 2.027 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 46.5133
timePerSpiralCoV 0.171109
timePerSpiralSlope -0.0329491
meanError 1.42742
tremorFreq 5.85938
tremorRelPower 28.8077
tremorGyroAmpMean 0.0119264
tremorGyroAmpSlope 0.000906705
tremorGyroAmpCoV 0.337988
tremorCoordAmpMean 0.0288216
tremorCoordAmpSlope 0.000924761
tremorCoordAmpCoV 0.298588
tremorAccAmpMean 0.0486138
tremorAccAmpSlope 0.00016067
tremorAccAmpCoV 0.183304
tremorPcRelVar 0.672583
tremorPcX 0.900289
tremorPcY 0.435293

Spiral Segment 1

Duration 61.36 s, Accuracy Estimate 1.493 (lower is better)

Spiral Segment 2

Duration 42.76 s, Accuracy Estimate 1.649 (lower is better)

Spiral Segment 3

Duration 39.64 s, Accuracy Estimate 1.308 (lower is better)

Spiral Segment 4

Duration 41.6 s, Accuracy Estimate 1.396 (lower is better)

Spiral Segment 5

Duration 44.56 s, Accuracy Estimate 1.317 (lower is better)

Spiral Segment 6

Duration 49.16 s, Accuracy Estimate 1.402 (lower is better)

Elel

eDurationMean 0.581707
eDurationStd 0.244094
eDurationStdnorm 0.419617
eDurationMedian 0.49
eDurationQuartdelta 0.23875
eDurationQuartdeltanorm 0.487245
eDurationKurt 7.34507
eDurationTrenddiff -0.1275
eDurationTrendratio 0.774336
eWidthMean 5.00817
eWidthStd 2.37962
eWidthStdnorm 0.475148
eWidthMedian 4.446
eWidthQuartdelta 2.77875
eWidthQuartdeltanorm 0.625
eWidthKurt 4.21673
eWidthTrenddiff 0
eWidthTrendratio 1
eHeightMean 8.62661
eHeightStd 3.67853
eHeightStdnorm 0.426417
eHeightMedian 8.307
eHeightQuartdelta 5.0895
eHeightQuartdeltanorm 0.612676
eHeightKurt 2.66348
eHeightTrenddiff -2.574
eHeightTrendratio 0.730061
eAspectMean 0.632028
eAspectStd 0.284829
eAspectStdnorm 0.450658
eAspectMedian 0.554054
eAspectQuartdelta 0.334529
eAspectQuartdeltanorm 0.603784
eAspectKurt 4.54597
eAspectTrenddiff 0.0990881
eAspectTrendratio 1.20732
eSlantMean -0.0971388
eSlantStd 0.340564
eSlantStdnorm -3.50595
eSlantMedian -0.0930233
eSlantQuartdelta 0.433951
eSlantQuartdeltanorm -4.66497
eSlantKurt 3.62862
eSlantTrenddiff 0.122001
eRtopMean 0.723009
eRtopStd 0.190994
eRtopStdnorm 0.264165
eRtopMedian 0.783784
eRtopQuartdelta 0.263861
eRtopQuartdeltanorm 0.336651
eRtopKurt 2.79275
eRtopTrenddiff 0.0906123
eRbotMean 1.02594
eRbotStd 0.568708
eRbotStdnorm 0.554328
eRbotMedian 0.959184
eRbotQuartdelta 0.501501
eRbotQuartdeltanorm 0.522842
eRbotKurt 3.72514
eRbotTrenddiff -0.283842
eRrightMean 0.790107
eRrightStd 0.194744
eRrightStdnorm 0.246478
eRrightMedian 0.825581
eRrightQuartdelta 0.212962
eRrightQuartdeltanorm 0.257953
eRrightKurt 8.15904
eRrightTrenddiff 0.137704
eRleftMean 0.422434
eRleftStd 0.161109
eRleftStdnorm 0.381382
eRleftMedian 0.428571
eRleftQuartdelta 0.224029
eRleftQuartdeltanorm 0.522733
eRleftKurt 2.42696
eRleftTrenddiff -0.115192
lDurationMean 0.842317
lDurationStd 0.362064
lDurationStdnorm 0.429843
lDurationMedian 0.7
lDurationQuartdelta 0.3175
lDurationQuartdeltanorm 0.453571
lDurationKurt 5.19189
lDurationTrenddiff -0.1275
lDurationTrendratio 0.840125
lWidthMean 7.62212
lWidthStd 1.91529
lWidthStdnorm 0.251281
lWidthMedian 7.605
lWidthQuartdelta 2.48625
lWidthQuartdeltanorm 0.326923
lWidthKurt 3.52873
lWidthTrenddiff -0.8775
lWidthTrendratio 0.892086
lHeightMean 24.2247
lHeightStd 5.7725
lHeightStdnorm 0.23829
lHeightMedian 23.634
lHeightQuartdelta 8.5995
lHeightQuartdeltanorm 0.363861
lHeightKurt 2.60537
lHeightTrenddiff -8.892
lHeightTrendratio 0.687885
lAspectMean 0.329026
lAspectStd 0.099517
lAspectStdnorm 0.302459
lAspectMedian 0.306667
lAspectQuartdelta 0.122418
lAspectQuartdeltanorm 0.399189
lAspectKurt 3.04908
lAspectTrenddiff 0.0544412
lAspectTrendratio 1.18189
lSlantMean -0.0439089
lSlantStd 0.153956
lSlantStdnorm -3.50626
lSlantMedian -0.0337838
lSlantQuartdelta 0.211034
lSlantQuartdeltanorm -6.24661
lSlantKurt 2.54854
lSlantTrenddiff 0.118808
lRtopMean 0.717663
lRtopStd 0.180357
lRtopStdnorm 0.251312
lRtopMedian 0.791667
lRtopQuartdelta 0.251
lRtopQuartdeltanorm 0.317053
lRtopKurt 3.09013
lRtopTrenddiff 0.18373
lRbotMean 0.972994
lRbotStd 0.46961
lRbotStdnorm 0.482644
lRbotMedian 0.912621
lRbotQuartdelta 0.554233
lRbotQuartdeltanorm 0.607298
lRbotKurt 4.21654
lRbotTrenddiff -0.229971
lRrightMean 0.840761
lRrightStd 0.105732
lRrightStdnorm 0.125757
lRrightMedian 0.858447
lRrightQuartdelta 0.111715
lRrightQuartdeltanorm 0.130136
lRrightKurt 6.23591
lRrightTrenddiff 0.0522134
lRleftMean 0.449562
lRleftStd 0.235536
lRleftStdnorm 0.523923
lRleftMedian 0.373333
lRleftQuartdelta 0.40038
lRleftQuartdeltanorm 1.07245
lRleftKurt 2.03887
lRleftTrenddiff -0.22909

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.905773
sumTouchScores 20.8328
meanMovementTime 0.824091
numTouches 23
undershootPercentage 0
overshootPercentage 13.0435

FITTS Long Modified

meanTouchScore 0.948157
sumTouchScores 13.2742
meanMovementTime 1.31462
numTouches 14
undershootPercentage 0
overshootPercentage 14.2857

ZigZag

numZigzags 5
timePerZigzagMean 48.568
timePerZigzagCoV 0.294767
timePerZigzagSlope -0.18053
meanError 2.29919
tremorFreq 5.46875
tremorRelPower 31.5763
tremorGyroAmpMean 0.0161227
tremorGyroAmpSlope 0.000847708
tremorGyroAmpCoV 0.443514
tremorCoordAmpMean 0.0373737
tremorCoordAmpSlope 0.00186271
tremorCoordAmpCoV 0.374919
tremorAccAmpMean 0.0361269
tremorAccAmpSlope 0.00146746
tremorAccAmpCoV 0.391266
tremorPcRelVar 0.685435
tremorPcX -0.674393
tremorPcY -0.738372

ZigZag Segment 1

Duration 69.48 s, Accuracy Estimate 2.104 (lower is better)

ZigZag Segment 2

Duration 52.28 s, Accuracy Estimate 2.399 (lower is better)

ZigZag Segment 3

Duration 47.64 s, Accuracy Estimate 2.103 (lower is better)

ZigZag Segment 4

Duration 43.32 s, Accuracy Estimate 2.153 (lower is better)

ZigZag Segment 5

Duration 30.12 s, Accuracy Estimate 2.737 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 20.08
timePerZigzagCoV 0.282268
timePerZigzagSlope -0.167928
zigzagHeightMean 81.1832
zigzagHeightCoV 0.0543885
zigzagHeightSlope 0.00529502
meanError 0.0461791
tremorFreq 6.25
tremorRelPower 30.2512
tremorGyroAmpMean 0.0258837
tremorGyroAmpSlope 0.000875389
tremorGyroAmpCoV 0.38176
tremorCoordAmpMean 0.0598624
tremorCoordAmpSlope 0.000881997
tremorCoordAmpCoV 0.34772
tremorAccAmpMean 0.0896687
tremorAccAmpSlope -0.000881643
tremorAccAmpCoV 0.144636
tremorPcRelVar 0.699467
tremorPcX 0.497272
tremorPcY -0.867594

ZigZag Offset Segment 1

Duration 28.56 s, Accuracy Estimate 0.055 (lower is better)

ZigZag Offset Segment 2

Duration 20.64 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 3

Duration 21.4 s, Accuracy Estimate 0.021 (lower is better)

ZigZag Offset Segment 4

Duration 15.56 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 5

Duration 14.24 s, Accuracy Estimate 0.085 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.57}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.63}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7665929607235817}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8881838642258166}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8356918293692512}